RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
mir-301a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
Forced expression of miR-130a in mouse lung; IInhibition of the miR-130/301 family in mouse lung; Oligonucleotides and transfectio etc.
Target
NA
Pathway
NA
PubMed ID
Title
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension
Year
2014
Function
"Analysis of the molecular network architecture specific to PH predicted that the miR-130/301 family is a master regulator of cellular proliferation in PH via regulation of subordinate miRNA pathways. In endothelial cells, miR-130/301 modulated apelin-miR-424/503-FGF2 signaling, while in smooth muscle cells, miR-130/301 modulated STAT3-miR-204 signaling to promote PH-associated phenotypes. In murine models, induction of miR-130/301 promoted pathogenic PH-associated effects, while miR-130/301 inhibition prevented PH pathogenesis."